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In humans, IGF-I also increases renal blood flow and GFR by ~25% and causes volume expansion and sodium retention by a direct action on the renal tubules, with stimulation of rennin release and suppression of atrial natriuretic peptide secretion[364]

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Angiogenesis-related FGFR4 is significantly upregulated in breast cancer, and promotes vascular endothelial cell proliferation and breast cancer angiogenesis via the PI3K/AKT signaling pathway 24

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