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MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

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doi: 10.1046/j.1469-8137.1999.00477.x 27 KassellB.BrandE

3 , e420 (2006)

If accessible, consider a baseline dermascopy evaluation from a dermatologist specializing in hair loss

They may also be necessary when certain medications interfere with B12 absorption or in any other diagnosed condition specifically impacting B12 uptake