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The tert-butyl moiety of compound 2 points to TM7 and makes hydrophobic contacts with A350 6.39b and K351 6.40b , replacement at the C-3 position by polar functional groups caused a dramatic decline in its potency and efficacy 38
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Cultures were incubated either at 25 C (mold phase) or 37 C (yeast phase) with continuous shaking at 200 rpm
The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(/) mice by blocking monocyte/macrophage activation
