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T-cell responses, evaluated through intracellular cytokine staining, indicate that 93.3% (14/15) of assessable patients exhibit SARS-CoV-2-specific T-cell responses following the initial dose, comprising CD 4+ responses in 80% and CD 8+ responses in 60%, with 80% demonstrating polyfunctional responses involving TNF-, IFN-, and IL-2

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 40% by weight of the poloxamer

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Although scientists are still trying to figure out the neurobiological reasons for depression, several working theories are driving research and treatment development