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Therefore, melatonin regulates several physiological functions, playing essential roles in regulating body temperature, metabolic control, glycemic and lipid control, cardiovascular and immune system control, reproduction and pregnancysuch as the secretion of gonadotropin-releasing hormone, gonadotropins, follicle-stimulating hormone, and luteinizing hormone neural development, and protection [2,3,4]

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In support of this is the fact that the concentrations of biomarkers of B 12 function, methylmalonic acid and homocysteine increase in the later stages of pregnancy (Reference Murphy, Molloy and Ueland57,Reference Milman, Byg and Bergholt58) suggesting some level of metabolic B 12 depletion in pregnant women