MOTS-c acts as a metabolic coordinator, linking mitochondrial health to nuclear gene expression, a critical communication system that often fails during aging and metabolic disease
Disparities between antioxidant activity and ROS levels can lead to oxidative stress
The full MS scan for both polarities used 120,000 resolution with an AGC target of 3 10 6 and a maximum IT of 100 ms, and the scan range was from 671,000 m / z
200ul HPLC grade water was added to each sample and the samples were transferred to autosampler vials
This reminds me Toni Vidal-Puig MD PhD FRCP FMedSci MAE MBA comment about organ vulnerability: obesity may be heterogeneous in terms of which organ becomes the first weak link in the chain of events that form vicious cycles
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