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This metabolic state arises from a dysregulation between uric acid production and elimination, culminating in its accumulation in the bloodstream

10.1159/000076764 Neuroimmunomodulation 4 AuclairY.RougetR.Affar elB.DrobetskyE

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The latter studies in mice, as well as our recent human study showing that combined EGCG and resveratrol supplementation affects flexibility of postprandial substrate oxidation without changes in systemic lipolysis 19 may suggest that skeletal muscle is a major target tissue for the EGCG-induced metabolic effects