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Predefined stopping rules and assay QC criteria (calibration curves, inter-assay CVs) are reported for transparency

Summary and future considerations Despite delivering significant weightloss and health benefits, GLP1 medications also present important limitations, including gastrointestinal side effects, nutrient shortfalls from the diet, loss of muscle mass, high costs, frequent discontinuation, and weight regain once treatment stops

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Different medication forms such as semaglutide versus tirzepatide could result in different nutrient intakes

GLP-1 medicines can change that biological pushback enough to make healthy habits more sustainable but they still work best when theyre part of a broader plan, not a replacement for one