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Human randomized controlled trial data are comparatively thin

In an oncogenic context, the IGF family regulates a number of biological processes such as cancer cell proliferation, apoptosis, metabolism and protein synthesis, which are closely associated with the activation of PI3K/AKT signaling, which subsequently promotes the transcription of downstream pro-oncogenic target genes such as c-Myc and HIF-1 (77)

Selenoamino acids, mineral forms of selenium and the regulation of the GSH-Px system To better understand this last point, we must look again at the remethylation and transsulfuration pathways but, this time, with the selenoamino acids, selenomethionine and selenocysteine (Figure 4)