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Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

Lipid peroxidation transpires when reactive oxygen species (ROS) target polyunsaturated fatty acids (PUFAs) inside cell membranes, resulting in the production of bioactive aldehydes such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE), which may conjugate with cellular macromolecules, impairing their functionality

Clin Infect Dis Off Publ Infect Dis Soc Am 37(8):9971005

Beneficial Microbes, 7 (1), 103110

One fascinating study published in the journal The Proceedings of the Nutrition Society describes how the process works

By causing glycosuria as their primary mechanism of action, they create a persistent bacterial growth medium in the urinary tract