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If you're also taking insulin or sulfonylureas, be aware of increased hypoglycemia risk and discuss potential dose adjustments of these medications

The medication must be taken on an empty stomach with no more than 4 ounces of plain water, and patients should wait at least 30 minutes before eating, drinking anything else, or taking other medications

Recommendations and Contraindications These combination therapies are particularly suited for patients with type 2 diabetes who are struggling to achieve target glucose levels with oral medication alone or who require both a GLP-1 receptor agonist and insulin but prefer to avoid multiple daily injections

Increase to 500 mcg on the second or third injection if tolerated

When could retatrutide receive FDA approval