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References 1 International Diabetes Federation

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Stenberg, E., Ottosson, J., Cao, Y., Lagstam, I

The area postrema and brainstem nuclei that signal satiety also mediate nausea, which is why appetite suppression and gastrointestinal upset so often travel together

Tirzepatide (weekly injectable) Dosing frequency: Once weekly, same day each week Half-life: approximately 5 days (120 hours) Peak concentration: 8 to 72 hours after injection Recommended timing approach: The shorter half-life compared to semaglutide means the end-of-week trough is more noticeable

So try not to overdo it