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In support to this notion, we have shown: (i) L-cysteine, an activator of H 2 S producing enzymes (CSE and CBS), or the exogenous H 2 S donors NaHS and GYY4137 inhibited OA-induced GLP-1 and PYY release, and (ii) inhibition of release is due to suppression of the Epac/PLC-/Ca 2+ pathway downstream of cAMP pathway

Reported side effects include [1][29]: Flatulence Loose stools Skin rash (rare) Flushing (rare) These side effects have generally been mild and self-limiting

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these enzymes are highly expressed in kidney and liver of mice, but exhibit low expression in muscle (47)