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According to clinical practice guidelines, combining a GLP-1 receptor agonist like semaglutide with metformin is generally considered safe and may enhance metabolic benefits

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It is well known that oxidative stress is involved in the development of many chronic diseases such as cancer ( Reference Reuter, Gupta and Chaturvedi 1 ) , CVD ( Reference Heitzer, Schlinzig and Krohn 2 ) and diabetes ( Reference Ceriello and Motz 3 )

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