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19%), despite adherence to standard preprocedural fasting guidelines [31]

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Regulatory and compounding status All four compounds share a broadly similar regulatory landscape in the United States as of 2026: None are FDA-approved as finished drug products for therapeutic use All are classified as WADA S2 prohibited substances year-round All four have 503A compounding status of Under Review, meaning the FDA Pharmacy Compounding Advisory Committee (PCAC) has nominated them for evaluation but final category assignments (Category 1 permitted for compounding

One area receiving increasing attention is their effect on GLP-1 , a powerful gut hormone that plays a central role in blood sugar balance, appetite regulation, and metabolic health

No Phase III

Generally, maintaining at least 72 hours between doses is the minimum safe interval for weekly injections, though aiming for as close to seven days as possible remains ideal