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Importantly, elevated KYNA in the CNS may contribute to cognitive deficits in schizophrenia by antagonizing 7nAChRs and NMDARs, which are critical for synaptic plasticity, working memory, and cortical network coordination [76, 240,241,242]

Our study is in corroboration with Bun et al

The specific activity of GPx ranged from 2.43 to 6.45 mol of GSH consumed in the enzymatic reaction, calculated per 1 minute and per 1 mg of protein ( n = 7)

Authors' contributions JMC participated in the coordination of the study, statistical analysis and interpretation of data, and helped to draft the study

Clinical trials as mentioned by the research studies have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial)

Diabetol Metab Syndr