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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

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These effects generally indicate either starting doses too high or individual sensitivity

Thats why intravenous delivery is most efficient and effective way to address most conditions caused by glutathione deficiency

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J Auton Nerv Syst 80:1421 rskov C, Rabenhj L, Wettergren A, Kofod H, Holst JJ (1994a) Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans