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van den Beld and colleagues 27 showed that higher serum IGFBP-2 levels were associated with a higher degree of disability and a lower physical performance, muscle strength, and bone mineral density of proximal femur

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Aging also raises the risks of age-related comorbidities like vascular and metabolic issues (431)

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Oxidative damage increases through exposure to UV radiation, pollution, pesticides, and smoke, as well as a diet high in inflammatory foods or low in antioxidant-rich foods