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Medical Contraindications There are situations where GLP-1 medications should not be used

They tirelessly build and repair linings and tissues in the skin, gut, liver, lungs, and digestive tract to maintain their integrity and functionality

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The mechanism is distinct from PDE5 inhibitors (which act peripherally on vascular smooth muscle) and from hormonal treatments (which modulate circulating hormone levels)

From a pharmacovigilance perspective, phentermine shows fewer serious adverse events than several newer agents when prescribed as monotherapy

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