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These data provide the first prospective evidence to support recent multisociety recommendations advocating for individualized, risk-based management rather than universal discontinuation of GLP-1 RAs

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Of note, despite their moderate price, their efficacy is often mitigated by patients poor adherence and their adverse effects that include hepatotoxicity [14], peripheral neuropathy, and gastrointestinal discomfort [15]

reduction in sustained decline in eGFR, kidney disease progression or end-stage kidney disease) and the tolerability of SGLT2is across the CKD spectrum [10,11,12]

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