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The alterations allow it to avoid binding to proteins in the body, allowing it to have a longer half-life

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More recently, it has become clear that these receptors are widely distributed throughout the central nervous system (CNS), which has raised the possibility of repurposing these drugs for neurological disorders

"Tirzepatide Once Weekly for the Treatment of Obesity." New England Journal of Medicine, 2022

If you're not already using tretinoin, start it now at 0.025% three nights per week and titrate upward