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Extracellular matrix collagen I differentially regulates the metabolic plasticity of pancreatic ductal adenocarcinoma parenchymal cell and cancer stem cell

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doi: 10.1016/j.bbamcr.2020.118883

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Vulnerability factors include early life trauma, poor social support, co-existing medical conditions, genetic predisposition and sex-based differences (Lai and Xiong, 2025)

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent