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Adults 18 and older on Medicare Part D who meet one of three BMI tiers at the time GLP-1 therapy is initiated: BMI 35, BMI 30 with a comorbidity (heart failure with preserved EF, uncontrolled hypertension despite two antihypertensives, or chronic kidney disease stage 3a+), or BMI 27 with a cardiovascular comorbidity (pre-diabetes by ADA criteria, prior heart attack, prior stroke, or symptomatic peripheral artery disease)

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While more research is necessary, there is some evidence that both drugs may prove useful as smoking cessation aids

Starting with the lowest effective doses of both compounds and gradually titrating upward allows for better symptom monitoring and safety assessment

This decline is primarily attributed to the reduced capacity for glutathione synthesis that comes with aging

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