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Timing of onset of adverse events with setmelanotide, an MC4R agonist, in patients with severe obesity due to LEPR or POMC deficiency

However, patients often notice the return of their original conditions, such as increased appetite, weight gain, or higher blood sugar levels

(Oxf.) 76, 4650.10.1111/j.1365-2265.2011.04139.x 172 Karczewska-KupczewskaM.StraczkowskiM.AdamskaA.NikolajukA.OtziomekE.GrskaM.et al (2010)

Dermato-Endocrinology 5, 264270

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Much of this pain reduction likely stems from the substantial weight loss reducing mechanical stress on joints