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The drug was also well tolerated, with mostly mild or moderate gastrointestinal-related adverse events that Roche said were "consistent with the safety profile of the incretin drug class," and will now progress to phase 2

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As compared to the normal group, the DRG concentrations of TNF- and i-NOS were markedly elevated in Res group rats to 3.5- folds and 2.88- folds, respectively

The integration between these datasets was assessed, and genes and lipids were mapped to relevant KEGG metabolic pathways for over-representation analysis, with significance determined by the False Discovery Rate (FDR)