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These modified GLP-1 analogues retain the beneficial properties while allowing practical therapeutic application

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Another consequence of obesity is chronic overactivity of the sympathetic nervous system, which, together with the previously described consequences of chronic obesity, induces hypertension and increases the risk of heart disease, stroke, and chronic kidney dysfunction (2, 6, 7) ( Figure 1 )

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Although there was a significant difference between the growth of vadK and vadK:vadK , complementation was incomplete, suggesting that expression of vad K from the chromosomally distant att B site where we re-inserted it into the genome using pMV306 under its native promoter was insufficient