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(2003), who described decreased ventricular CSF orexin levels in PD patients, which were related with the severity of the disease, other authors have confirmed decreased CSF orexin in PD (Fronczek et al., 2007

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[27], which similarly demonstrated a significant reduction in composite kidney outcomes, primarily driven by the efficacy of GLP-1RAs in reducing macroalbuminuria without significantly preventing worsening of kidney function