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Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

Each additional receptor contributes a distinct metabolic effect: GIP modulates insulin secretion and adipose handling, glucagon contributes to energy expenditure [3][4]

GLP-1R plays a role in the central nervous system (CNS) regulation of appetite

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Additionally, these medicines may influence central nervous system pathways involved in appetite regulation