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In non-industry sponsored analyses, net costs per quality-adjusted life year have ranged from $237,000-$483,000 [79], with low cost-effectiveness related to plateauing of weight benefits but continued costs of treatment, as well as weight regain following any cessation of use

This creates an individualized optimization challenge: finding the lowest dose that produces satisfactory results while minimizing adverse effects

In: UpToDate , Basow, DS (Ed), Waltham, MA

Tesamorelin operates through an entirely different pathway

Cardiovasc Diabetol 14 , 129 (2015)