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These are real serious concerns

Even before GLP-1 reaches systemic circulation, this local portal GLP-1 signal produces strong effects on glucose uptake and insulin sensitivity in the liver and pancreas

As with any new drug, talk to a doctor first.

All authors reviewed and revised the manuscript

Danuglipron: Developed by Pfizer and intended to keep blood glucose at healthy levels, this oral GLP-1 recently completed Phase 2 clinical trials for the treatment of type 2 diabetes and obesity

These BP reductions are associated with improvements in left ventricular structure and function, as well as peripheral vascular health