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Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

Capsules can be taken with or without food, and the powder can be added to food or drink.

Tirzepatide (Zepbound) was not included as that drug was only approved for obesity late in 2023

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There is considerable observational evidence linking B-vitamins involved in OCM with the risk of HDP