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The pathophysiology of both FGIDs is based on a combination of motility disturbances, visceral hypersensitivity, low grade mucosal immune activation, and altered processing of gut-brain-signals

It is usually a documentation gap, which means the second submission, prepared with the gap addressed, tends to succeed

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Non-arteritic anterior ischemic optic neuropathy, or NAION, is a sudden, painless loss of vision caused by a failure of blood supply to the optic nerve head

The drug release at pH 1.2 remained below 30%, whereas there was a rapid and extensive drug release of about 70% observed within 1 h at pH 7.4