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Cell 54 , 183195 (2020)

& Rempe, D

Boelaert JR, Weinberg GA, Weinberg ED

These ice crystals have sharp edges that can literally shear and denature the protein

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Key Takeaways Intestinal permeability is a regulated biological process studied in gastroenterology and immunology Leaky gut is a non-clinical term describing patterns linked to increased permeability The gut barrier is influenced by tight junctions, the mucus layer, microbes, and microbial metabolites Short-chain fatty acids (SCFAs) play a central role in barrier regulation Increased permeability is context-dependent and not always harmful Long-term gut barrier support focuses on regulation and resilience, not sealing the gut Why This Distinction Matters Confusing these terms can lead to: Fear-based health messaging Overdiagnosis Unsubstantiated treatment claims Science does not recognize leaky gut as a standalone disease