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The D-alanine substitution at position 2 is specifically directed at blocking the primary DPP-4 cleavage site, while the remaining substitutions prevent additional enzymatic attack at susceptible positions and reduce oxidative degradation during storage and in vivo

10.3390/ijms18071415 179 ShahbaziM

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Homeost Agents 29, 265272

Ebselen derivative 1 demonstrates significant protective effects against cisplatin (HY-17394)-induced hair cell (HC) damage both in vitro and in vivo , effectively reducing oxidative stress, apoptosis , and ferroptosis in hair cells

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