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Most TPE treatments in the United States use the centrifugation method, which separates blood components into layers of red blood cells, plasma, platelets, granulocytes, monocytes, and lymphocytes according to density

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Mechanisms differ, and they can be synergistic

The body does not produce vitamin B12, so it must be obtained from dietary sources or supplements

Rotate the injection site nightly across different quadrants of the abdomen to avoid localized irritation over the 10-day cycle