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For thyroid C-cell tumors specifically, the FDA requires a boxed warningthe agency's strongest safety warningfor several products including semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), exenatide extended-release (Bydureon BCise), and tirzepatide (Mounjaro, Zepbound)

In less than two years, the percentage of American adults using these meds for weight loss has roughly doubled, rising from 5.8% to 12%, according to a recent Gallup report

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Oncogene 19 , 10771084 (2000)

Many patients beginning GLP-1 therapy simultaneously reduce their food intake significantly, which can lead to muscle soreness if they do not consume adequate protein or electrolytes during this transition