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Recent systemic review and meta-analysis demonstrated, that treatment with functional agonists of GLP-1 which included both GLP-1RAs and DPP4 inhibitors resulted in a significant reduction of depression rating scores and tended to be superior over control treatments, which supports the hypothesis of their antidepressant action in humans

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10.1016/j.biopha.2020.110669 Biomed Pharmacother

Medications such as orlistat (a pancreatic lipase inhibitor) carry FDA approval for ages 12 and up and represent a lower-risk starting point

Definition of the analysis populations ITT and full analysis set For the ITT sample, all randomized participants were used for the analyses except those who withdrew or were lost to follow-up