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PMID: 225 HowellSJCasbardACarucciMIngarfieldKButlerRMorganSet al

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Here, we first combined different metabolic markers based on their degree of variance and then selected the most relevant metabolites explaining the persistence of symptoms using an ML-based feature selection consensus

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That means the registered study cannot currently be used as public evidence for oral BPC bioavailability

Thus, once MTHFR has reduced 5,10-methyleneTHF to 5-MTHF, the Vitamin B12 dependent methionine synthase, encoded by MTR, uses this reduced folate to convert Hcy back into methionine