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Winkler, E

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Three proteins from the SLC19A membrane transporter family are responsible for the transport of thiamine to animal tissue cells

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization

Age-related changes in kidney function can also slow clearance, particularly in patients over 65, potentially requiring dose adjustments or longer intervals between administrations