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IGF-1-1 and IGF-2 are primarily produced in the liver and to a lesser extent locally in target tissues where they exert autocrine and paracrine actions

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ARRIVE guidelines statement : The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines

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Preclinical Studies in Ototoxicity Models A study carried out both in cultured cells and in an animal model (male and female mice) demonstrated the strong beneficial potential of ALA in rescuing ototoxic hearing loss caused by cisplatin