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10.3390/MOLECULES30071525/S1 60

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It did not take long, however, for the first major controversy regarding SUs to emerge, when tolbutamide was deemed to have caused an excess of cardiac deaths by the University Group Diabetes Program (UGDP), leading to the premature termination of this limb of its multicenter, placebo-controlled clinical trial [16]

Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination