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The potential clinical relevance of this finding relates to the dose-limiting effect of nausea with existing GLP-1R agonists

It activates multiple target receptor subtypes for broad systemic effects studied in preclinical models

[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

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120 Long-acting GLP-1 RAs remain in the body for an extended period (eg, with a mean residence time [MRT] of 224 hours at a steady state after administering 14 mg of oral semaglutide)