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From 25 to 45 days of age mice rapidly put on weight, which then plateaued for the duration of the study (Fig

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The proportion of participants achieving clinically meaningful weight loss thresholds at 48 weeks on the 12 mg dose: - 5% weight loss: 100% - 10% weight loss: 93% - 15% weight loss: 83% For comparison, placebo achieved 5% in 27%, 10% in 9%, and 15% in just 2%