This signaling helps you feel satisfied sooner during meals and reduces the urge to keep eating (NIH)
One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)
A Note on "Triple Antagonist" vs "Triple Agonist" Searches for "triple antagonist peptide" are common in the Canadian peptide community, but the correct term is "triple agonist peptide." The distinction matters chemically: Agonist: Activates a receptor
5,6 Without the appropriate GLP-1 activation, insulin is not released promptly, and glucagon production releases glucose into the bloodstream, contributing to elevated blood glucose levels
The appetite suppression feels like second nature
Mounjaro and Zepbound are tirzepatide