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Clinical context matters

Vitamin B12, along with folate and B6, powers methylationthe biochemical engine that allows HNMT to neutralize histamine

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Patients should contact their healthcare provider if they experience any of the following: Severe or worsening fatigue that interferes with daily activities, work, or self-care, or fatigue that progressively worsens despite implementing management strategies

For example, according to the National Institutes of Health (NIH), adults between 19 and 50 years old should consume 2.4 micrograms of vitamin B12 per day

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