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(2023) also observed this dose- and time-dependent relationship, demonstrating that physiological adaptation occurs progressively during treatment, reducing the intensity and frequency of adverse effects after the second month of use

Some state pharmacy boards have issued rules limiting prescriptions, including Texas, Louisiana, Ohio and North Carolina.

While preclinical results are promising, clinical trials reveal considerable variability, highlighting the need for personalized approaches and robust biomarkers

Reddy's decision reflects a quality-first approach that could strengthen confidence among regulators, healthcare professionals, and patients

He et al., 2024)