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This is also where the maintenance question becomes important, because the duration of GLP-1 agonist therapy directly impacts long-term outcomes

Further in vivo studies indicated that P

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Mol Pharmacol : Epub ahead of print

Common side effects include nausea, vomiting, diarrhea, and constipation, but most of these symptoms improve over time

Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)