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Studies have revealed that mice lacking ZIP14 display a disruption in the tight junction complex and increased permeability, potentially due to impaired zinc-dependent activation of ZnR/GPR39

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The authors attributed this effect to the lipophilicity of the esterified derivatives of GSH

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Kari OK, Ndika J, Parkkila P, Louna A, Lajunen T, Puustinen A, et al