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This is different from intravenous injection, where large air volumes can cause serious complications

Ma L, Ju P, Wang W, et al

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Consequently, the magnitude of weight loss benefit in multi-agonist therapies has shown dependence on glucagon activity: a balanced ratio of GLP-1 and glucagon receptors co-agonism achieves maximal weight loss without hyperglycaemia in contrast to dual-agonists with lower glucagon receptor potency or enhanced glucagon receptor activity [89]

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