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The culmination of this process is beta-cell death, a gradual and irreversible loss of insulin-producing capacity due to this multifaceted immune attack that ultimately leads to clinical hyperglycemia [74, 75] (Fig

The combination of arginine deprivation and 5-fluorouracil improves therapeutic efficacy in argininosuccinate synthetase negative hepatocellular carcinoma

As for any experimental model, there are limitations to the different mouse models used in our study

The therapeutic index based upon animal studies is small

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Intramuscular injection Intramuscular injection delivers HCG into muscle tissue, typically the deltoid (upper arm) or the vastus lateralis (outer thigh)